亚新体育_湖人主场致敬科比 http://asahijapaneselanguageschool.com/content/journals/14761645?TRACK=RSS Please follow the links to view the content. 乐动体育实力怎么样_火神山10天10夜 http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0754?TRACK=RSS <div></div> Wed, 08 Jan 2020 00:00:00 GMT http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0754?TRACK=RSS A. Clinton White Jr. and Agnes Fleury 2020-01-08T00:00:00Z 乐动体育官网活动_教授柯卉兵病逝 http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0755?TRACK=RSS <div></div> Wed, 08 Jan 2020 00:00:00 GMT http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0755?TRACK=RSS Matthew Grant 2020-01-08T00:00:00Z 乐动体育水晶宫_国乒首秀4金收官 http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0204?TRACK=RSS <div></div> Wed, 08 Jan 2020 00:00:00 GMT http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0204?TRACK=RSS Monique Boukobza, Sylvie Lariven, Sandrine Houz¨¦ and Jean-Pierre Laissy 2020-01-08T00:00:00Z 乐动体育规则_日本撤侨官疑自杀 http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0539?TRACK=RSS <div></div> Wed, 08 Jan 2020 00:00:00 GMT http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0539?TRACK=RSS Koju Kamoi and Kyoko Ohno-Matsui 2020-01-08T00:00:00Z LDSport乐动网址_粉丝要金钟大退队 http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0473?TRACK=RSS <div></div> Wed, 08 Jan 2020 00:00:00 GMT http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0473?TRACK=RSS Zachary Tabb 2020-01-08T00:00:00Z 乐动体育南安普顿_湖南延迟复工开学 http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0463?TRACK=RSS <div><span class="tl-main-part">Abstract.</span> <p>Residency programs are increasingly responding to the growing demand for global health (GH) education by forming dedicated GH tracks. These tracks incorporate a targeted curriculum, support best practices surrounding GH electives such as predeparture preparation and post-return debriefing, and encourage meaningful engagement with international and domestic partners. The University of Minnesota&#8217;s pediatric residency has had a formal GH track since 2005, and although they have shared several curricular components in the literature, they have yet to provide a comprehensive summary of their GH track. In this article, the authors provide a thorough description of their evolving GH track model, highlighting outcomes and sharing free resources, with the goal of providing a concise, replicable GH track framework for educators seeking to provide more formal GH education within residency programs.</p></div> Wed, 08 Jan 2020 00:00:00 GMT http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0463?TRACK=RSS Michael B. Pitt, Tina M. Slusher, Sophia P. Gladding, Risha Moskalewicz and Cynthia R. Howard 2020-01-08T00:00:00Z 五星体育官网_刘亚仁声援武汉 http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0512?TRACK=RSS <div><span class="tl-main-part">Abstract.</span> <p>Severe thrombocytopenia with impairment of the activity of platelets and impairment of blood clotting occurs in dengue hemorrhagic fever (DHF). Continuation of dual antiplatelet therapy in such patients can result in life-threatening hemorrhages. On the other hand, withholding of antiplatelets in a patient undergone coronary stenting lately can lead to stent thrombosis, resulting in myocardial infarctions and sudden cardiac death. There are no guidelines on management of DHF in patients with coronary stents. Here, we discuss about several divergent factors that need to be considered and balanced when managing such patients. We describe a case as an example to illustrate how we balanced the risk of serious bleeding versus the risk of stent thrombosis successfully according to evolution of the disease process, by temporary withholding of antiplatelets in such a patient.</p></div> Wed, 08 Jan 2020 00:00:00 GMT http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0512?TRACK=RSS N. D. B. Ehelepola, A. A. S. D. Athurupana, P. G. C. S. Bowatte and Wasantha P. Dissanayake 2020-01-08T00:00:00Z LDDD乐动官网_上海北欧式领口罩 http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0458?TRACK=RSS <div><span class="tl-main-part">Abstract.</span> <p>Pneumonia is one of the leading causes of death in children under 5 years worldwide. In resource-limited settings, WHO recommendations state that pneumonia can be presumptively diagnosed through the presence of cough and/or difficult breathing and a respiratory rate (RR) that is higher than age-specific cutoffs. As a new diagnostic aid the children&#8217;s automated respiration monitor (ChARM) can automatically measure and classify RR in children under 5 years, but the effect of its chest attachment on the RR has not been studied. The aim of this study was to understand if misclassification of the true RR occurred by ChARM attachment. Two hundred eighty-seven children at a health center in South Ethiopia were screened for eligibility, with 188 children aged 2&#8211;59 months enrolled in the study. The RR was measured manually before and 1, 3, and 5 minutes after ChARM attachment. The proportion of children with fast or normal RR classification at baseline and the change between RR classifications over time were analyzed. Eight (4.9%; 95% CI 2.1, 9.4) of 163 children changed RR classification from normal to fast between the baseline RR count and the 1 minute RR count. Results from this study suggest that ChARM has a minor influence on the RR of children immediately after attachment, in most cases without clinical importance.</p></div> Wed, 08 Jan 2020 00:00:00 GMT http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0458?TRACK=RSS Daniel Helld¨¦n, Kevin Baker, Tedila Habte, Esey Batisso, Nicola Orsini, Karin K?llander and Tobias Alfv¨¦n 2020-01-08T00:00:00Z 乐动体育心水_意甲 http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0405?TRACK=RSS <div><span class="tl-main-part">Abstract.</span> <p>Globally, diarrheal and respiratory infections are responsible for more than 24% of deaths in children aged less than 5 years. Historically, these disease entities have been studied separately; recent evidence suggests that preceding diarrheal disease may be a risk factor for subsequent respiratory illness. We used data from a community-based, prospective randomized trial of maternal influenza immunization of 3,693 pregnant women and their 3,646 infants conducted in rural Nepal from 2011 to 2014. A case-crossover design was used to determine whether the risk of respiratory infection in the 30 days following a diarrheal episode was increased compared with that 30 days prior. Diarrheal illness was a significant risk factor for subsequent respiratory illness in infants but not in women during pregnancy or in women up to six months postpartum. Diarrheal illness and respiratory infections remain important global sources of morbidity and mortality, and our study supports a causal relationship between them in infants.</p></div> Wed, 08 Jan 2020 00:00:00 GMT http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0405?TRACK=RSS Kira L. Newman, Kathryn Gustafson, Janet A. Englund, Subarna K. Khatry, Stephen C. LeClerq, James M. Tielsch, Joanne Katz and Helen Y. Chu 2020-01-08T00:00:00Z 滚球竞彩APP_葛洪升逝世 http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0542?TRACK=RSS <div><span class="tl-main-part">Abstract.</span> <p>There are hundreds of millions of internal migrants in China, and tuberculosis (TB) is an important health threat to them. However, the mental health problems of internal migrants with TB in China have been ignored. The present study aimed to determine the prevalence of depressive symptoms and its associated risk factors among internal migrants with TB in China. A cross-sectional survey was conducted between June 2018 and March 2019 in Shenzhen, southern China. Data were collected from 1,057 internal migrants with TB using a structured questionnaire. Depressive symptoms were measured using the Center for Epidemiologic Studies Depression Scale. Multinomial logistic regression analysis was used to identify risk factors for depressive symptoms. Of the 1,057 participants included in this study, 53.8% had depressive symptoms. Of these, 38.9% had mild, whereas 14.9% had moderate-to-severe depressive symptoms. Multinomial logistic regression analysis suggested that higher likelihoods of depressive symptoms were associated with female gender, lower education, family dysfunction, poor doctor&#8211;patient communication, and TB-related stigma. This study shows that the prevalence of depressive symptoms among internal migrants with TB is high in China. Targeting interventions and treatment of depressive symptoms among internal migrants with TB are needed.</p></div> Wed, 08 Jan 2020 00:00:00 GMT http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0542?TRACK=RSS Xiaoxin Dong, Lingbo Zhao, Tongda Sun, Fei Yun and Lei Qiu 2020-01-08T00:00:00Z 乐动体育马德里竞技_日本撤侨官疑自杀 http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0264?TRACK=RSS <div><span class="tl-main-part">Abstract.</span> <p> <span class="jp-italic">Mycobacterium africanum</span> (MAF) is known to endemically cause up to 40&#8211;50% of all pulmonary TB in West Africa. The aim of this study was to compare MAF with <span class="jp-italic">Mycobacterium tuberculosis</span> (MTB) with regard to time from symptom onset to TB diagnosis, and clinical and radiological characteristics. A cross-sectional study was conducted in Bamako, Mali, between August 2014 and July 2016. Seventy-seven newly diagnosed pulmonary TB patients who were naive to treatment were enrolled at Mali&#8217;s University Clinical Research Center. Sputum cultures were performed to confirm the diagnosis and spoligotyping to identify the mycobacterial strain. Univariate and multivariate analyses were used to identify factors associated with disease progression. Overall, the frequency of female patients was 25% in MAF infection and only 10.0% in MTB infection (OR = 2.9), and MAF was more represented in patients aged &#8805; 30 years (57.1% versus 36.7% [OR = 2.3]). More MAF- than MTB-infected patients had a history of a prior TB contact (32.1% versus 14.3% [OR = 2.8]). The mean duration between cough onset and TB diagnosis was 111 days (&#8764;3.7 months) for MAF and 72 days (&#8764;2.4 months) for MTB (<span class="jp-italic">P</span> = 0.007). In a multivariate regression, weight loss (body mass index [BMI] &lt; 18.5 kg/m<span class="jp-sup">2</span>) and cough duration (&gt; 4 months) were strongly associated with MAF infection (OR = 5.20 [1.49&#8211;18.26], <span class="jp-italic">P</span> = 0.010, and 4.74 [1.2&#8211;18.58], <span class="jp-italic">P</span> = 0.02), respectively. Our data show that MAF infection was significantly associated with lower BMI and a longer time between symptom onset and TB diagnosis than MTB. This supports the concept that MAF infection may have slower disease progression and less severe cough symptoms than MTB.</p></div> Wed, 08 Jan 2020 00:00:00 GMT http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0264?TRACK=RSS Bocar Baya, Bassirou Diarra, Seydou Diabate, Bourahima Kone, Drissa Goita, Yeya dit Sadio Sarro, Keira Cohen, Jane L. Holl, Chad J. Achenbach, Mohamed Tolofoudie, Antieme Combo Georges Togo, Moumine Sanogo, Amadou Kone, Ousmane Kodio, Djeneba Dabitao, Nadie Coulibaly, Sophia Siddiqui, Samba Diop, William Bishai, Sounkalo Dao, Seydou Doumbia, Robert Leo Murphy, Souleymane Diallo and Mamoudou Maiga 2020-01-08T00:00:00Z 体育网上商城乐动体育_武汉中心医院辟谣 http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0401?TRACK=RSS <div><span class="tl-main-part">Abstract.</span> <p>In addition to the complications of leprosy, people affected by leprosy (PALs) can suffer from chronic diseases. We evaluated the recent pattern of deaths among Korean PALs and compared it with that in the general population. We analyzed the death certificate data of 1,359 PALs from 2010 through 2013. The all-cause and cause-specific standardized mortality ratio (SMR) and standardized mortality with 95% CI were calculated. Malignancy had the highest standardized mortality, with 130.9 deaths per 100,000 persons, followed by cardiovascular diseases (CVDs; 85.5 deaths) and respiratory diseases (38.2 deaths). Of malignancies, liver cancer caused the greatest number of cancer deaths (40.0 deaths). The all-cause mortality of PALs was significantly lower than that in the general population, corresponding to an SMR of 0.84 (95% CI 0.79&#8211;0.88). Deaths from malignancy and CVDs were significantly lower, corresponding to SMRs (95% CIs) of 0.88 (0.79&#8211;0.98) and 0.75 (0.67&#8211;0.84), respectively. The death rates for lung and stomach cancers were lower, whereas mortality due to liver cancer was higher, with an SMR of 1.79 (95% CI 1.43&#8211;2.22). Except for liver cancer and infection, the causes of mortality of PALs tend to be lower than that in the general population. The most common underlying cause of death in PALs was stroke, followed by ischemic heart disease, liver cancer, and pneumonia.</p></div> Wed, 08 Jan 2020 00:00:00 GMT http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0401?TRACK=RSS Young-Hwan Ahn, Hyungcheol Park and Sun-Seog Kweon 2020-01-08T00:00:00Z 体育投注站官网_四川地震 http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0241?TRACK=RSS <div><span class="tl-main-part">Abstract.</span> <p>The attenuated recombinant <span class="jp-italic">Vibrio cholerae</span> O1 vaccine strain CVD 103-HgR, redeveloped as PXVX0200, elicits a rapid serum vibriocidal antibody (SVA) response and protects against cholera-induced diarrhea in adult volunteer challenge trials but has not been studied in children in developed countries. We performed a phase 4, placebo-controlled, double-blind, multicenter study to assess the safety, immunogenicity, and tolerability of a single, oral dose of PXVX0200 in children and adolescents aged 6&#8211;17 years in the United States and bridged immunogenicity to adults aged 18&#8211;45 years from a separate lot consistency study. Volunteers were randomized to receive a single dose of 1 &#215; 10<span class="jp-sup">9</span> colony forming units (CFU) of PXVX0200 or placebo. Immunogenicity endpoints included SVA levels on days 1, 11, and 29 in volunteers aged 6&#8211;17 years and also on days 91 and 181 in volunteers aged 12&#8211;17 years. Safety was assessed by comparing solicited signs and symptoms on days 1&#8211;8, unsolicited adverse events (AEs) through day 29, and serious AEs through day 181. A total of 374 participants were enrolled, comprising 321 vaccine and 53 placebo recipients. The SVA seroconversion rates 10 days after immunization were 98.6% and 2.1% in vaccine and placebo recipients, respectively, and the vaccine seroconversion rate was non-inferior to the 93.5% rate seen in adults aged 18&#8211;45 years. Most reactogenicity was mild to moderate, and there were no vaccine-related serious AEs. The complete dose was consumed in 95.3% and 98.1% of vaccine and placebo recipients, respectively. PXVX0200 appears safe, immunogenic, and well tolerated in children and adolescents aged 6&#8211;17 years.</p></div> Wed, 08 Jan 2020 00:00:00 GMT http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0241?TRACK=RSS James M. McCarty, Emma C. Gierman, Lisa Bedell, Michael D. Lock and Sean Bennett 2020-01-08T00:00:00Z LDsports 开户_我是特种兵之火凤凰 http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.16-0840?TRACK=RSS <div><span class="tl-main-part">Abstract.</span> <p>Nontyphoidal <span class="jp-italic">Salmonella</span> infections can result in bacteremia. This study was undertaken to determine the predictive factors for bacteremia in children aged less than 16 years. Medical data were collected for every child with positive nontyphoidal <span class="jp-italic">Salmonella</span> cultures in blood or stools at the University hospital of Martinique, French West Indies, between January 2005 and December 2015. Among 454 patients, 333 were included; 156 cases had confirmed bacteremia, and 177 were included as control group with nontyphoidal <span class="jp-italic">Salmonella</span> only isolated in stools. Age at diagnosis, delay before consulting, prematurity, immunosuppression, or hyperthermic seizures were not significantly associated with bacteremia. C-reactive protein was higher in cases of bacteremia (<span class="jp-italic">P</span> = 0.01); however, after adjusting to the threshold of 30 mg/L, there was no longer any difference. There were also significant relations for electrolytes such as hyponatremia (odds ratio (OR) = 2.08 [95% CI = 1.31&#8211;3.95]; <span class="jp-italic">P</span> &lt; 0.01), high urea level (OR = 0.53 [95% CI = 0.32&#8211;0.88], <span class="jp-italic">P</span> &lt; 0.01). The infecting serotype was the most discriminant risk factor (<span class="jp-italic">P</span> &lt; 10<span class="jp-sup">&#8722;4</span>). Among 28 serotypes isolated between 2005 and 2015, <span class="jp-italic">Salmonella panama</span> was the most common serotype: 122 strains (78.2%) were isolated from bacteremic patients versus 60 (33.9%) from nonbacteremic patients (<span class="jp-italic">P</span> &lt; 10<span class="jp-sup">&#8722;4</span>). <span class="jp-italic">Salmonella panama</span> was the most important risk factor for bacteremia (OR = 7.37 [95% CI = 3.18&#8211;17.1], <span class="jp-italic">P</span> &lt; 10<span class="jp-sup">&#8722;4</span>) even after multivariate analysis (OR = 13.09 [95% CI = 5.42&#8211;31.59], <span class="jp-italic">P</span> &lt; 10<span class="jp-sup">&#8722;4</span>). After adjusting for bacteremia, <span class="jp-italic">S. panama</span> was associated with a significantly higher body temperature than other <span class="jp-italic">Salmonella</span>: 39&#176;C (standard deviation [SD] = 0.92) versus 38.2&#176;C [SD = 1.1], linear regression <span class="jp-italic">P</span> &lt; 10<span class="jp-sup">&#8722;3</span>. Children with <span class="jp-italic">Salmonella</span> serotype panama infection were at higher risk of bacteremia than children infected with other <span class="jp-italic">Salmonella</span> serotypes.</p></div> Wed, 08 Jan 2020 00:00:00 GMT http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.16-0840?TRACK=RSS Arnaud Buteux, Mathieu Nacher, C¨¦lia Merat, Duc Nguyen, Benoit Roze, Andr¨¦ Cabi¨¦ and Claude Olive 2020-01-08T00:00:00Z 乐动体育云达不莱梅_疫情拐点将出现 http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0498?TRACK=RSS <div><span class="tl-main-part">Abstract.</span> <p>Scrub typhus is a life-threatening zoonotic disease, which is caused by <span class="jp-italic">Orientia tsutsugamushi</span>, an obligatory intracellular Gram-negative bacterium. It is transmitted by <span class="jp-italic">Leptotrombidium</span> mites in endemic regions of Southeast Asia. So far, data on imported scrub typhus cases to non-endemic areas and immunological descriptions are rare. Eleven scrub typhus cases that had been diagnosed by the German National Reference Center for Tropical Pathogens between 2010 and 2018 were retrospectively reviewed for clinical symptoms, laboratory changes, and travel destinations. Patient sera were included if follow-up samples showed simultaneous seroconversion for IgM and IgG antibody responses by immunofluorescence assays or concurrence with the first serum sample. The median of seroconversion was week 2 after symptom onset. Cytokine levels were measured over time, demonstrating simultaneously upregulated major Th1, Th2, and Th17 cytokines in the acute phase of infection followed by normalization during convalescence. This study underlines the complex mixed cytokine response elicited by scrub typhus and highlights clinical and diagnostic aspects of imported infections with <span class="jp-italic">O. tsutsugamushi</span>.</p></div> Wed, 08 Jan 2020 00:00:00 GMT http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0498?TRACK=RSS Philip Eisermann, Jessica Rauch, Stefan Reuter, Lukas Eberwein, Ute Mehlhoop, Petra Allartz, Birgit Muntau and Dennis Tappe 2020-01-08T00:00:00Z 乐动体育链接_尹正蒋梦婕恋情 http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.18-0242?TRACK=RSS <div><span class="tl-main-part">Abstract.</span> <p> <span class="jp-italic">Angiostrongylus cantonensis</span> is a zoonotic, parasitic nematode causing angiostrongyliasis or rat lungworm disease. Clinical diagnosis in humans is currently confirmed by detection of parasite DNA in cerebrospinal fluid. This study estimated human exposure to <span class="jp-italic">A. cantonensis</span> in volunteer participants solicitated via public venues on east Hawai&#8217;i Island using blood-based tests. Antibodies were screened in sera by crude antigen ELISA, followed by a 31-kDa dot-blot test developed and validated in Thailand. Human participants (<span class="jp-italic">n</span> = 435) donated blood samples and completed a questionnaire to self-report relevant symptomology or clinical diagnosis. Among symptoms reported by participants diagnosed by licensed clinicians, headaches, high eosinophil counts, stiff neck, fatigue, and joint pain were most severe during the initial 3 months of infection. ELISA results revealed 22% of the serum samples as positive, 46% as equivocal, and 32% as negative. A subset of 186 samples was tested by dot blot, with 30% testing positive and 70% testing negative. A significantly higher mean ELISA value was found among recently (2014&#8211;2015) clinically diagnosed participants as than among those with a diagnosis before 2010 (<span class="jp-italic">P</span> = 0.027). All dot-blot positives were also ELISA positive and were significantly associated with higher ELISA values compared with dot-blot negatives (<span class="jp-italic">P</span> = 0.0001). These results suggest that an ELISA using crude antigen isolated from adult <span class="jp-italic">A. cantonensis</span> from Hawai&#8217;i may be an effective initial screening method for estimating exposure to <span class="jp-italic">A. cantonensis</span> in Hawai&#8217;i and likewise suggest that dot-blot tests using the 31-kDa antigen exhibit efficacy as a diagnostic for exposure.</p></div> Wed, 08 Jan 2020 00:00:00 GMT http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.18-0242?TRACK=RSS Susan I. Jarvi, Praphathip Eamsobhana, Stefano Quarta, Kathleen Howe, Steven Jacquier, Alexandra Hanlon, Kirsten Snook, Robert McHugh, Zachariah Tman, Jill Miyamura, Kuilei Kramer and McKayla Meyer 2020-01-08T00:00:00Z 池州乐动体育_国乒包揽女单四强 http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0436?TRACK=RSS <div><span class="tl-main-part">Abstract.</span> <p>Subarachnoid neurocysticercosis (SUBNCC) is usually caused by an aberrant proliferative form of <span class="jp-italic">Taenia solium</span> causing mass effect and arachnoiditis. Thirty of 34 SUBNCC patients were treated with extended cysticidal and anti-inflammatory regimens and followed up a median of 4.2 years posttreatment (range: 15 for &#8805; 4 years, 20 &#8805; 2 years, 26 &gt; 1 year, and 3 &lt; 1 year). The median ages at the time of first symptom, diagnosis, and enrollment were 29.7, 35.6, and 37.9 years, respectively; 58.8% were male and 82.4% were Hispanic. The median time from immigration to symptoms (minimum incubation) was 10 years and the estimated true incubation period considerably greater. Fifty percent also had other forms of NCC. Common complications were hydrocephalus (56%), shunt placement (41%), infarcts (18%), and symptomatic spinal disease (15%). Thirty patients (88.2%) required prolonged treatment with albendazole (88.2%, median 0.55 year) and/or praziquantel (61.8%; median 0.96 year), corticosteroids (88.2%, median 1.09 years), methotrexate (50%, median 1.37 years), and etanercept (34.2%, median 0.81 year), which led to sustained inactive disease in 29/30 (96.7%) patients. Three were treated successfully for recurrences and one has continuing infection. Normalization of cerebral spinal fluid parameters and cestode antigen levels guided treatment decisions. All 15 patients with undetectable cestode antigen values have sustained inactive disease. There were no deaths and moderate morbidity posttreatment. Corticosteroid-related side effects were common, avascular necrosis of joints being the most serious (8/33, 24.2%). Prolonged cysticidal treatment and effective control of inflammation led to good clinical outcomes and sustained inactive disease which is likely curative.</p></div> Wed, 08 Jan 2020 00:00:00 GMT http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0436?TRACK=RSS Theodore E. Nash, Elise M. O¡¯Connell, Dima A. Hammoud, Lauren Wetzler, JeanAnne M. Ware and Siddhartha Mahanty 2020-01-08T00:00:00Z 乐动体育软件app_全明星致敬科比 http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0572?TRACK=RSS <div><span class="tl-main-part">Abstract.</span> <p>Cystic echinococcosis (CE) is a zoonotic disease caused by the larval stage of the cestode <span class="jp-italic">Echinococcus granulosus</span>. The parasite typically infects dogs and ungulates, with humans acting as dead-end hosts. Information on the epidemiology of CE is lacking from Central Asia, including from Kazakhstan where CE cases are reported centrally. This study presents data from the Kazakhstan Scientific and Practical Center for Sanitary and Epidemiological Evaluation and Monitoring on CE patients treated surgically, with a diagnosis confirmed by pathology. Evaluation of data from 2007 to 2016 indicated that the CE incidence rate decreased during this time period in most areas of Kazakhstan (country-level incidence rate of 5.6 versus 4.7 cases/100,000 population in 2007 and 2016, respectively). Cystic echinococcosis had a higher incidence in southern Kazakhstan, with an incidence rate between 7.0 and 10.5 cases per 100,000 population, whereas northern regions had rates less than 4.0 cases per 100,000 population. Moreover, despite the overall decrease, CE incidence continues to increase in the south. Cystic echinococcosis surveillance is needed, particularly in the south, to help inform policymakers and orient disease control efforts.</p></div> Wed, 08 Jan 2020 00:00:00 GMT http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0572?TRACK=RSS Aigerim Mustapayeva, Tommaso Manciulli, Zhamilya Zholdybay, Konrad Juskiewicz, Zhanar Zhakenova, Zhanna Shapiyeva, Zhumagul Medetov, Ambra Vola, Mara Mariconti, Enrico Brunetti, Christine M. Budke, Maira Khalykova and Amangul Duisenova 2020-01-08T00:00:00Z 乐动体育官方真网_建议单位错峰吃饭 http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0532?TRACK=RSS <div><span class="tl-main-part">Abstract.</span> <p>Fear of adverse events (AEs) negatively affects compliance to mass drug administration (MDA) for lymphatic filariasis (LF) elimination program. Systemic AEs are believed to occur because of killing of microfilariae, whereas localized soft tissue reactions might be due to the death of adult worms following therapy. Most AEs are mild and self-limited. However, localized AEs are sometimes more significant and of concern to participants. Here, we describe localized AEs that were noted during a large community study that evaluated the safety of a triple-drug regimen (ivermectin, diethylcarbamazine, and albendazole) for the treatment of LF in India. We have also discussed the importance of timely detection and careful management of AEs for preserving community confidence in MDA.</p></div> Wed, 08 Jan 2020 00:00:00 GMT http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0532?TRACK=RSS Vijesh Sreedhar Kuttiatt, Roopali K. Somani, Subramanian Swaminathan, Kaliannagounder Krishnamoorthy, Gary J. Weil and Jambulingam Purushothaman 2020-01-08T00:00:00Z 乐动体育莱斯特城_湖北确诊9074例 http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0428?TRACK=RSS <div><span class="tl-main-part">Abstract.</span> <p> <span class="jp-italic">Schistosoma mansoni</span> infection negatively impacts children&#8217;s physical health and may influence general well-being. Schistosomiasis control programs aim at reducing morbidity through mass drug administration (MDA). This study aimed to compare morbidity markers between two cohorts of Tanzanian schoolchildren with initial high prevalence of <span class="jp-italic">S. mansoni</span> infection. One cohort (<span class="jp-italic">N</span> = 254 at baseline) received annual MDA for 4 years using community-wide treatment (CWT). The second cohort (<span class="jp-italic">N</span> = 318 at baseline) received school-based treatment (SBT) every other year for 4 years. At year 5, the CWT cohort and the SBT cohort were reduced to 153 and 221 children, respectively. The characteristics of the 198 children lost to follow-up did not differ at baseline from those who were examined in year 5. <span class="jp-italic">Schistosoma mansoni</span> infection<span class="jp-italic">,</span> hemoglobin (Hb) and anemia, physical fitness, and perceived quality of life were investigated at baseline, year 3, and year 5, whereas liver and spleen pathology (ultrasound) were investigated only at baseline and year 5. Cohorts were compared using two-way mixed-model analysis of variance (ANOVA). Both treatment regimens significantly decreased individual-level mean intensity of <span class="jp-italic">S. mansoni</span> infection, anemia, and hepatomegaly, and increased Hb levels after 5 years. Hepatomegaly was the only parameter affected by the treatment regimen as the CWT approach reduced the percentage of individuals with hepatomegaly significantly more than the SBT approach. Both treatment regimens led to reduced physical fitness at year 5 compared with baseline. The modest impact of the two control strategies are probably due to initial low intensity of infection, ensuring low level of schistosomiasis-related morbidity.</p></div> Wed, 08 Jan 2020 00:00:00 GMT http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0428?TRACK=RSS Annette Olsen, Safari Kinung¡¯hi, Godfrey Kaatano and Pascal Magnussen 2020-01-08T00:00:00Z 乐动体育官方app_停课不停学 http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0671?TRACK=RSS <div><span class="tl-main-part">Abstract.</span> <p>We report a case of <span class="jp-italic">Fasciola hepatica</span> liver abscesses in a 67-year-old female returning from a trip to Vietnam. She has been suffering from a fever, right abdominal pain for 4 days, and major eosinophilia. Radiologic investigations showed multiple hypodense confluent abscesses in the right lobe of the liver, complicated by occlusive thrombosis of the right branch of the portal vein. The serological investigation of helminth-elicited eosinophilia showed only a positive serology for <span class="jp-italic">F. hepatica.</span> Despite repeated negative stool examinations for any intestinal pathogen, the diagnosis was established by the detection of <span class="jp-italic">F. hepatica</span> DNA in stool and pus aspirate samples.</p></div> Wed, 08 Jan 2020 00:00:00 GMT http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0671?TRACK=RSS Coralie L¡¯Ollivier, Carole Eldin, Emilie Lambourg, Philippe Brouqui and Jean Christophe Lagier 2020-01-08T00:00:00Z 乐动体育澳彩_欧文54分 http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0432?TRACK=RSS <div><span class="tl-main-part">Abstract.</span> <p>The infection dynamics of <span class="jp-italic">Opisthorchis viverrini</span> metacercariae was analyzed in cyprinid fish from endemic areas in Mukdahan Province, Thailand, and Khammouane Province, Lao PDR. The fish were collected during the cool-dry (November&#8211;February), hot-dry (March&#8211;May), and rainy (June&#8211;October) seasons in 2017. They were examined by the digestion method, and the infection status was statistically analyzed by study area, season, and fish size. The prevalence (no. of fish positive/no. of fish examined &#215; 100) and metacercarial intensities (no. of metacercariae detected/no. of fish positive) of <span class="jp-italic">O. viverrini</span> in both study areas depended on season, being high in the cool-dry season and varying in the hot-dry and rainy seasons. In Mukdahan Province, the average prevalence was 18.3% (range 11.0&#8211;46.7%, <span class="jp-italic">n</span> = 420) and the intensity was 4.07 &#177; 5.86 cysts/fish (mean &#177; SD), whereas in Khammouane Province, the prevalence was 51.9% (range 9.1&#8211;70.6%, <span class="jp-italic">n</span> = 673) and the intensity was 6.67 &#177; 12.88 cysts/fish. Among the cyprinid fish species examined, the infection was associated with fish body size and predominantly found in <span class="jp-italic">Hampala dispar</span> (86.5%), <span class="jp-italic">Cyclocheilichthys armatus</span> (73.2%), and <span class="jp-italic">Puntius brevis</span> (42.7%). The distribution of <span class="jp-italic">O. viverrini</span> metacercariae in fish was skewed, with most of the fish having a low worm burden with an average of four to six cysts/fish. The findings that seasonality, sampling locality, fish size, and species of fish play roles in the risk of <span class="jp-italic">O. viverrini</span> infection imply that these host and environmental factors are important for the transmission dynamics and control of <span class="jp-italic">O. viverrini</span>.</p></div> Wed, 08 Jan 2020 00:00:00 GMT http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0432?TRACK=RSS Jutamas Namsanor, Nadda Kiatsopit, Thewarach Laha, Ross H. Andrews, Trevor N. Petney and Paiboon Sithithaworn 2020-01-08T00:00:00Z 乐动体育捡白菜_湖南卫监局长去世 http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0106?TRACK=RSS <div><span class="tl-main-part">Abstract.</span> <p>Ethiopia aims to diagnose and treat all clinical malaria within 24 hours of fever onset in its stride to eliminate the disease by 2030. Microscopy remains to be the mainstay for diagnosis at the health center and hospital level. Continuous evaluation and performance upgrading of malaria microscopists is one of the cornerstones in this effort. We assessed the performance of malaria microscopists compared with reference readers in diagnosing, identifying the species, and quantifying parasitemia. A total of 174 microscopists were enrolled from health facilities located in 86 districts in Oromia region (Ethiopia) from January 2017 to June 2018. Panel slides with known <span class="jp-italic">Plasmodium</span> species, diagnostic blood stage, and parasite density were prepared by the reference readers. Sociodemographics, education, in-service training, and routine practice of participants were captured. Sensitivity, specificity, percent agreement, and kappa score were calculated. An overall low performance was observed that could threaten the malaria diagnostic service. Of all the slides distributed (1,218), only 17.0% of the positive and 30.0% of the negative slides were correctly identified and 22.4% were correctly quantified. Compared with the reference readers, participants had lower competence in diagnosing (74.3% agreement and kappa 0.45) and identifying the species (71.2% agreement and kappa 0.40). Two-fifths of the participants were graded as &#8220;in training&#8221; with respect to identifying the species (41.0%) and the diagnostic stages (40.0%). An in-service training/retraining and supportive supervision are needed to raise and maintain the competence of microscopists in settings with a recent decline in malaria transmission and aiming for ultimate elimination of the disease.</p></div> Wed, 08 Jan 2020 00:00:00 GMT http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0106?TRACK=RSS Sagni Challi, Hirpa Miecha, Demekech Damtie, Girma Shumie, Wakweya Chali, Tsegaye Hailu, Taye Tolera Balcha, Fitsum G. Tadesse and Endalamaw Gadisa 2020-01-08T00:00:00Z www.LD SPORTS.com_两小无猜 http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0368?TRACK=RSS <div><span class="tl-main-part">Abstract.</span> <p>The epidemiology of febrile illness etiologies is under-explored in resource-poor settings. Establishing a local repertory of microorganisms circulating in blood of febrile and afebrile people is important for physicians. Blood was collected from 428 febrile and 88 afebrile children in Makokou (Gabon) and analyzed using polymerase chain reaction. <span class="jp-italic">Plasmodium</span> spp. were the pathogens, which were most detected in febrile children (69.6%; 298/428) and in afebrile children (31.8%; 28/88) (<span class="jp-italic">P</span> &lt; 0.0001). <span class="jp-italic">Plasmodium falciparum</span> was the most prevalent species in both febrile and afebrile children (66.8% and 27.3%, respectively). No differences were observed between febrile and afebrile children for <span class="jp-italic">Plasmodium malariae</span> and <span class="jp-italic">Plasmodium ovale</span> (8.2% versus 10.2% and 3.3% versus 3.4%, respectively). Triple infection with <span class="jp-italic">P. falciparum</span>, <span class="jp-italic">P. malariae</span>, and <span class="jp-italic">P. ovale</span> was also detected in 1% of febrile children (4/428). Filariasis due to <span class="jp-italic">Mansonella perstans</span> was detected in 10 febrile patients (2.3%), whereas <span class="jp-italic">Loa loa</span> was detected in both febrile and afebrile children (1.4% and 2.3%, respectively). Bacterial DNA was detected in only 4.4% (19/428) of febrile children, including 13 (68.4%) who were coinfected with at least one <span class="jp-italic">Plasmodium</span> species. These were <span class="jp-italic">Haemophilus influenzae</span> (1.6%, 7/428), <span class="jp-italic">Streptococcus pneumoniae</span> and <span class="jp-italic">Staphylococcus aureus</span> (1.2%, 5/428), and <span class="jp-italic">Rickettsia felis</span> (0.9%, 4/428). <span class="jp-italic">Coxiella burnetii</span>, <span class="jp-italic">Bartonella</span> spp., <span class="jp-italic">Borrelia</span> spp., <span class="jp-italic">Tropheryma whipplei</span>, <span class="jp-italic">Anaplasma</span> spp., <span class="jp-italic">Leptospira</span> spp., <span class="jp-italic">Streptococcus pyogenes</span>, and <span class="jp-italic">Salmonella</span> spp. were not detected. This study also highlights the over-prescription and the overuse of antibiotics and antimalarials. Overall, malaria remains a major health problem in Makokou. Malaria control measures must be reconsidered in this region.</p></div> Wed, 08 Jan 2020 00:00:00 GMT http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0368?TRACK=RSS C¨¦lia Scherelle Boumbanda Koyo, Sandrine Lydie Oyegue-Liabagui, Oleg Mediannikov, S¨¦bastien Cortaredona, Lady Charlene Kouna, Didier Raoult, Jean Bernard Lekana-Douki and Florence Fenollar 2020-01-08T00:00:00Z 乐动体育赛事热评_活塞买断莫里斯 http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0378?TRACK=RSS <div><span class="tl-main-part">Abstract.</span> <p>To implement future malaria elimination strategies in French Guiana, a characterization of the infectious reservoir is recommended. A cross-sectional survey was conducted between October and December 2017 in the French Guianese municipality of St Georges de l&#8217;Oyapock, located along the Brazilian border. The prevalence of <span class="jp-italic">Plasmodium</span> spp<span class="jp-italic">.</span> was determined using a rapid diagnostic test (RDT) and a polymerase chain reaction (PCR). Demographic, house locations, medical history, and biological data were analyzed. Factors associated with <span class="jp-italic">Plasmodium</span> spp. carriage were analyzed using logistic regression, and the carriage localization was investigated through spatial cluster analysis. Of the 1,501 samples analyzed with PCR, positive results totaled 90 and 10 for <span class="jp-italic">Plasmodium vivax</span> and <span class="jp-italic">Plasmodium falciparum</span>, respectively. The general PCR prevalence was 6.6% [5.3&#8211;7.9], among which 74% were asymptomatic. Only 13/1,549 were positive by RDT. In multivariate analysis, participants older than 15 years, living in a remote neighborhood, with a prior history of malaria, anemia, and thrombocytopenia were associated with an increased odds of <span class="jp-italic">Plasmodium</span> spp. carriage. High-risk clusters of <span class="jp-italic">P. vivax</span> carriage were detected in the most remote neighborhoods on the village outskirts and two small foci in the village center. We also detected a hot spot for both <span class="jp-italic">P. vivax</span> and <span class="jp-italic">P. falciparum</span> symptomatic carriers in the northwestern part of the village. The present study confirms a wide-scale presence of asymptomatic <span class="jp-italic">P. falciparum</span> and <span class="jp-italic">P. vivax</span> carriers in this area. Although they were more often located in remote areas, their geographic distribution was spatially heterogeneous and complex.</p></div> Wed, 08 Jan 2020 00:00:00 GMT http://asahijapaneselanguageschool.com/content/journals/10.4269/ajtmh.19-0378?TRACK=RSS Emilie Mosnier, Emmanuel Roux, Claire Cropet, Yassamine Lazrek, Olivier Moriceau, M¨¦lanie Gaillet, Luana Mathieu, Mathieu Nacher, Magalie Demar, Guillaume Odonne, Maylis Douine, C¨¦line Michaud, St¨¦phane Pelleau, F¨¦lix Djossou and Lise Musset 2020-01-08T00:00:00Z